What role do cytokines play in the body's response to tissue damage?

Cytokines are crucial signaling proteins that mediate and regulate immunity, inflammation, and the formation of blood cells. When tissue damage occurs, cytokines are released by damaged cells and other immune cells to communicate and coordinate the body’s response. Their role in alerting leukocytes, such as macrophages and neutrophils, to migrate to the site of injury or infection is particularly important. This recruitment helps to initiate the healing process, as leukocytes are responsible for clearing debris and pathogens, as well as stimulating further immune responses. The ability of cytokines to facilitate this communication is essential for an effective immune response and promotes recovery from tissue damage.